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An Efficient Pd-Catalyzed Coupling of Hydrazine Derivatives with Aryl Halides

Fang-Fang Ma, Zhi-Yong Peng, Wan-Fang Li, Xiao-Min Xie, Zhaoguo Zhang*

*School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. of China, Email:

F.-F. Ma, Z.-Y. Peng, W.-F. Li, X.-M. Xie, Z. Zhang, Synlett, 2011, 2555-2558.

DOI: 10.1055/s-0030-1260337

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The use of a catalytic amount of palladium, a MOP-type ligand, and Cs2CO3 enables a convenient method for the intermolecular N-arylation of hydrazides with aryl halides. The reaction gives coupled products in very good yields and tolerates a wide spectrum of functional groups.

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Key Words

palladium, MOP ligands, aryl halide, N-aryl hydrazides, N-arylation

ID: J60-Y2011-3060