Organic Chemistry Portal



Highly Efficient Copper- and Palladium-Free One-Pot Coupling of Alkynes with Sodium Carboxylate Salts Using Cyanuric and Magnesium Chlorides

Mohammad Navid Soltani Rad*, Somayeh Behrouz*

*Department of Chemistry, Shiraz University of Technology, Shiraz 71555-313, Iran, Email:,

M. N. S. Rad, S. Behrouz, Synlett, 2011, 2562-2566.

DOI: 10.1055/s-0030-1260336


The presence of magnesium chloride, cyanuric chloride, and triethylamine enables a highly efficient copper- and palladium-free cross-coupling of terminal alkynes with structurally diverse sodium carboxylate salts to furnish the corresponding ynones in very good yields at room temperature.

see article for more examples

Key Words

one-pot synthesis, alkynes, cyanuric chloride, sodium carboxylate salts, ynones

ID: J60-Y2011-3090