Mechanistic Studies on a New Catalyst System (CuI-NaHSO4•SiO2) Leading to the One-Pot Synthesis of Imidazo[1,2-a]pyridines from Reactions of 2-Aminopyridines, Aldehydes, and Terminal Alkynes
Sarita Mishra, Rina Ghosh*
*Department of Chemistry, Jadavpur University, Kolkata 700032, India, Email: ghoshrinayahoo.com
S. Mishra, R. Ghosh, Synthesis, 2011, 3463-3470.
DOI: 10.1055/s-0030-1260255
Abstract
One-pot reactions of aldehydes, 2-aminopyridines, and terminal alkynes, in the presence of the copper(I) iodide-NaHSO4•SiO2 combination catalyst in refluxing toluene, generates the corresponding imidazo[1,2-a]pyridines in high to excellent yields.
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Key Words
CuI-NaHSO4•SiO2, one-pot synthesis, imidazo[1,2-a]pyridines, 2-aminopyridine, cascade reaction, multicomponent reactions
ID: J66-Y2011-3180