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A Simple and Efficient Metal-Free Synthesis of Tetrasubstituted Pyrroles by Iodine-Catalyzed Four-Component Coupling Reaction of Aldehydes, Amines, Dialkyl Acetylenedicarboxylates, and Nitromethane

Biswanath Das*, Nisith Bhunia, Maram Lingaiah

*Organic Chemistry Division 1, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Email:

B. Das, N. Bhunia, M. Lingaiah, Synthesis, 2011, 3471-3474.

DOI: 10.1055/s-0030-1260228


A simple, efficient, cost-effective, and metal-free four-component coupling reaction of aldehydes, amines, dialkyl acetylenedicarboxylates, and nitromethane furnished the corresponding 1,2,3,4-tetrasubstituted pyrroles under reflux in the presence of molecular iodine as a catalyst in high yields within 8 hours.

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An Efficient New Method for the Synthesis of Polysubstituted Pyrroles

B. Das, G. C. Reddy, P. Balasubramanyam, B. Veeranjaneyulu, Synthesis, 2010, 1625-1628.

Key Words

1,2,3,4-tetrasubstituted pyrroles, multicomponent reactions, iodine, metal-free synthesis

ID: J66-Y2011-3230