A Simple and Efficient Metal-Free Synthesis of Tetrasubstituted Pyrroles by Iodine-Catalyzed Four-Component Coupling Reaction of Aldehydes, Amines, Dialkyl Acetylenedicarboxylates, and Nitromethane
Biswanath Das*, Nisith Bhunia, Maram Lingaiah
*Organic Chemistry Division 1, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Email: biswanathdasyahoo.com
B. Das, N. Bhunia, M. Lingaiah, Synthesis, 2011, 3471-3474.
A simple, efficient, cost-effective, and metal-free four-component coupling reaction of aldehydes, amines, dialkyl acetylenedicarboxylates, and nitromethane furnished the corresponding 1,2,3,4-tetrasubstituted pyrroles under reflux in the presence of molecular iodine as a catalyst in high yields within 8 hours.
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B. Das, G. C. Reddy, P. Balasubramanyam, B. Veeranjaneyulu, Synthesis, 2010, 1625-1628.