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Palladium-Catalyzed Hiyama Cross-Coupling of Aryltrifluorosilanes with Aryl and Heteroaryl Chlorides

Gary A. Molander* and Laura Iannazzo

*Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States, Email:

G. A. Molander, L. Iannazzo, J. Org. Chem., 2011, 76, 9102-9108.

DOI: 10.1021/jo201840n


An efficient, palladium-catalyzed Hiyama cross-coupling reaction of aryltrifluorosilanes with aryl chlorides enables the preparation of various functionalized biaryl derivatives in good to excellent yields. The scope of this reaction has also been extended to heteroaryl chlorides, affording the corresponding heterobiaryl compounds in high yields.

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Key Words

Hiyama Coupling, Biaryls, Heterobiaryls

ID: J42-Y2011-3280