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Polyethylene Glycol (PEG-400) as an Efficient and Recyclable Reaction Medium for the One-Pot Synthesis of N-Substituted Azepines under Catalyst-Free Conditions

Raghu Mallepalli, Lingappa Yeramanchi, Rajashaker Bantu, Lingaiah Nagarapu*

*Organic Chemistry Division-II, Indian Institute of Chemical Technology, Hyderabad 500 607, India, Email:

R. Mallepalli, L. Yeramanchi, R. Bantu, L. Nagarpu, Synlett, 2011, 2730-2732.

DOI: 10.1055/s-0031-1289542 (free Supporting Information)


Polyethylene glycol (PEG) is an inexpensive nontoxic and effective medium for the one-pot synthesis of N-substituted azepines under catalyst-free conditions in excellent yields. Environmental acceptability, low cost, high yields, and recyclability of the PEG are the important features of this protocol.

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Key Words

anilines, dialkylacetylene dicarboxylates, 2,5-dimethoxytetrahydrofuran, N-substituted azepines, azepines, polyethylene glycol, catalyst-free conditions, green chemistry, multicomponent reactions

ID: J60-Y2011-3300