TEMPO Oxoammonium Salt-Mediated Dehydrogenative Povarov/Oxidation Tandem Reaction of N-Alkyl Anilines
Heinrich Richter and Olga García Mancheño*
*Organisch-Chemisches Institut, Münster University,
Corrensstrasse 40, 48149 Münster, Germany,
Email: olga.garcia
uni-muenster.de
H. Richter, O. G. Mancheño, Org. Lett., 2011, 13, 6066-6069.
DOI: 10.1021/ol202552y
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Abstract
A one-pot dehydrogenative Povarov/oxidation tandem reaction of N-alkyl anilines with mono- and 1,2-disubstituted aryl and alkyl olefins enables the synthesis of a various substituted quinolines. The simple protocol uses cheap and benign iron(III)chloride as the Lewis acid catalyst and a TEMPO oxoammonium salt as a nontoxic, mild, efficient oxidant.
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Key Words
ID: J54-Y2011-3350
