Organic Chemistry Portal



Ammonium Phosphorodithioate: A Mild, Easily Handled, Efficient, and Air-Stable Reagent for the Conversion of Amides into Thioamides

Babak Kaboudin*, Leila Malekzadeh

*Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Gava Zang, Zanjan 45137-66731, Iran, Email:

B. Kaboudin, L. Malekzadeh, Synlett, 2011, 2807-2810.

DOI: 10.1055/s-0031-1289859


The reaction of various aromatic and aliphatic amides in the presence of ammonium phosphorodithioate as an efficient thionation reagent proceeded effectively to afford the corresponding thioamides in high yields. This method is easy, rapid, and high-yielding for the synthesis of thioamides from amides using an easily handled reagent.

see article for more examples

proposed mechanism

Phosphorus Pentasulfide: A Mild and Versatile Reagent for the Preparation of Thioamides from Nitriles

B. Kaboudin, D. Elhamifar, Synthesis, 2006, 224-226.

Key Words

thioamides, amides, phosphorodithioates, thionation

ID: J60-Y2011-3360