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Manganese Dioxide Catalyzed N-Alkylation of Sulfonamides and Amines with Alcohols under Air

Xiaochun Yu, Chuanzhi Liu, Lan Jiang and Qing Xu*

*College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China, Email:

X. Yu, C. Liu, L. Jiang, Q. Xu, Org. Lett., 2011, 13, 6184-6187.

DOI: 10.1021/ol202582c


A catalytic amount of manganese dioxide and solvent-free conditions under air enabled a practical and efficient N-alkylation method for a variety of sulfonamides and amines using alcohols as green alkylating reagents.

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Key Words

benzyl amines, sulfonamides, manganese dioxide

ID: J54-Y2011-3460