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A Powerful Palladium-Catalyzed Multicomponent Process for the Preparation of Oxazolines and Benzoxazoles

Patrick J. Boissarie, ZoŽ E. Hamilton, Stuart Lang*, John A. Murphy and Colin J. Suckling

*WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL United Kingdom, Email:

P. J. Boissarie, Z. E. Hamilton, S. Lang, J. A. Murphy, C. J. Suckling, Org. Lett., 2011, 13, 6184-6187.

DOI: 10.1021/ol202725y (free Supporting Information)


Efficient and convenient three-component couplings of aryl halides, amino alcohols and tert-butyl isocyanide under palladium catalysis provide a range of oxazolines in excellent yield. The use of 1,2-amino phenols instead of amino alcohols enables the synthesis of benzoxazoles.

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Key Words

Oxazolines, Benzoxazoles, Multicomponent Reaction

ID: J54-Y2011-3500