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Phase Separation As a Strategy Toward Controlling Dilution Effects in Macrocyclic Glaser-Hay Couplings

Anne-Catherine Bédard and Shawn K. Collins*

*Département de Chimie, Centre for Green Chemistry and Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec H3C 3J7 Canada, Email:

A.-C. Bédard, S. K. Collins, J. Am. Chem. Soc., 2011, 133, 19976-19981.

DOI: 10.1021/ja208902t (free Supporting Information)


Phase separation of the catalyst and substrate enables a macrocyclization strategy conducted at high concentrations. PEG400, a green and efficient solvent can be utilized in biphasic mixtures for promoting macrocyclization based on Glaser-Hay coupling at high concentrations with copper complexes, that are soluble in this highly polar phase.

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Key Words

Glaser-Hay Coupling

ID: J48-Y2011-3530