Catalyst-Free Preparation of 1,2,4,5-Tetrasubstituted Imidazoles from a Novel Unexpected Domino Reaction of 2-Azido Acrylates and Nitrones
Bao Hu*, Zhao Wang, Ning Ai*, Jie Zheng, Xing-Hai Liu, Shang Shan and Zhongwen Wang
*College of Chemical Engineering and Materials Science,
Zhejiang University of Technology, Hangzhou 310014, PR China,
Email: aining
zjut.edu.cn, hubao001zjut.edu.cn
B. Hu, Z. Wang, N. Ai, J. Zheng, X.-H. Liu, S. Shan, Z. Wang, Org. Lett., 2011, 13, 6362-6365.
DOI: 10.1021/ol202650z
Abstract
A highly efficient and convenient method for the synthesis of 1,2,4,5-tetrasubstituted imidazoles from readily accessible 2-azido acrylates and nitrones proceeded under mild conditions without the assistance of any metal, acid, or base.
see article for more examples
Key Words
ID: J54-Y2011-3570
