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Catalyst-Free Preparation of 1,2,4,5-Tetrasubstituted Imidazoles from a Novel Unexpected Domino Reaction of 2-Azido Acrylates and Nitrones

Bao Hu*, Zhao Wang, Ning Ai*, Jie Zheng, Xing-Hai Liu, Shang Shan and Zhongwen Wang

*College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, PR China, Email:,

B. Hu, Z. Wang, N. Ai, J. Zheng, X.-H. Liu, S. Shan, Z. Wang, Org. Lett., 2011, 13, 6362-6365.

DOI: 10.1021/ol202650z


A highly efficient and convenient method for the synthesis of 1,2,4,5-tetrasubstituted imidazoles from readily accessible 2-azido acrylates and nitrones proceeded under mild conditions without the assistance of any metal, acid, or base.

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ID: J54-Y2011-3570