Organic Chemistry Portal

Abstracts

Search:

Transition-Metal-Catalyzed Uninterrupted Four-Step Sequence to Access Trisubstituted Isoxazoles

Eric Gayon, Ophélie Quinonero, Sébastien Lemouzy, Emmanuel Vrancken* and Jean-Marc Campagne*

*Institut Charles Gerhardt UMR 5253 CNRS-UM2-UM1-ENSCM, 8 rue de l’Ecole Normale, 34296 Montpellier Cedex 5, France, Email: emmanuel.vranckenenscm.fr, jean-marc.campagneenscm.fr

E. Gayon, O. Quinonero, S. Lemouzy, E. Vrancken, J.-M. Campagne, Org. Lett., 2011, 13, 6418-6421.

DOI: 10.1021/ol202719n (free Supporting Information)


Abstract

The sequential use of iron and palladium catalysts in an uninterrupted four-step sequence allows the synthesis of trisubstituted isoxazoles from readily available propargylic alcohols. The advantages of such a strategy are illustrated by the high overall yields and the time-saving procedure.

see article for more examples



Key Words

Isoxazoles


ID: J54-Y2011-3610