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An Efficient Copper-Catalyzed One-Pot Synthesis of Diaryl Thioethers by Coupling of Arylboronic Acids with Potassium Ethyl Xanthogenate under Mild Conditions

Liang Wang*, Wei-You Zhou, Sheng-Chun Chen, Ming-Yang He, Qun Chen

*Key Laboratory of Fine Petro-Chemical Technology, Changzhou University, Changzhou 213164, P. R. of China, Email: liangwangcczu.edu.cn

L. Wang, W.-Y. Zhou, S.-C. Chen, M.-Y. He, Q. Chen, Synlett, 2011, 3041-3045.

DOI: 10.1055/s-0031-1289874


Abstract

Coupling of arylboronic acids with potassium ethyl xanthogenate enables a simple and environmentally benign one-pot synthesis of diaryl thioethers through a double arylation process. The aryl thiols were generated in situ, and the reactions proceeded smoothly to give the corresponding products in good to excellent yields under very mild conditions.

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Key Words

diaryl thioethers, arylboronic acids, potassium ethyl xanthogenate, one-pot synthesis, copper-catalyzed, Chan-Lam coupling


ID: J60-Y2011-3630