One-Pot Three-Component Synthesis of 4(3H)-Quinazolinones from Benzyl Halides, Isatoic Anhydride, and Primary Amines
Mehdi Adib*, Ehsan Sheikhi, Hamid Reza Bijanzadeh
*School of Chemistry, University College of Science,
University of Tehran, P. O. Box 14155-6455, Tehran, Iran, Email: madib
khayam.ut.ac.ir
M. Adib, E. Sheikhi, H. R. Bijanzadeh, Synlett, 2012, 23, 85-88.
DOI: 10.1055/s-0031-1290098
Abstract
Benzyl halides, that are first oxidized to aldehydes under mild Kornblum conditions, undergo a three-component reaction with isatoic anhydride and primary amines to produce 4(3H)-quinazolinones in excellent yields.
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Key Words
benzyl halides, Kornblum oxidation, isatoic anhydride, amines, 4(3H)-quinazolinones, multicomponent reactions
ID: J60-Y2012-0060
