Enantioselective Palladium-Catalyzed [3 + 2] Cycloadditions of Trimethylenemethane with Nitroalkenes
Barry M. Trost*, Dustin A. Bringley and Pamela S. Seng
*Department of Chemistry, Stanford University, Stanford,
California 94305-5080, United States,
Email: bmtrost
stanford.edu
B. M. Trost, D. A. Bringley, P. S. Seng, Org. Lett., 2012, 14, 234-237.
DOI: 10.1021/ol2030179
Abstract
Nitroalkenes readily undergo palladium-catalyzed [3 + 2] cycloaddition with trimethylenemethane to generate nitrocyclopentanes in excellent yield and enantioselectivity. Nitrocyclopentanes are highly versatile synthetic intermediates and provide convenient access to both cyclopentylamines and cyclopentenones.
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Key Words
ID: J54-Y2012-0070
