tert-Butoxide-Assisted Amidation of Esters under Green Conditions

Bo Ram Kim, Hyung-Geun Lee, Seung-Beom Kang, Gi Hyeon Sung, Jeum-Jong Kim, Jong Keun Park*, Sang-Gyeong Lee, Yong-Jin Yoon*

*Department of Chemistry & Research Institute of Natural Sciences, Graduate School for Molecular Materials and Nanochemistry, Gyeongsang National University, Jinju 660-701, Korea, Email: yjyoongnu.ac.kr, mc7gnu.ac.kr

B. R. Kim, H.-G. Lee, S.-B. Kang, G. H. Sung, J.-J. Kim, J. K. Park, S.-G. Lee, Y.-J. Yoon, Synthesis, 2012, 44, 42-50.

DOI: 10.1055/s-0031-1289622

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Abstract

Aliphatic and/or aromatic esters were converted into the corresponding amides under mild conditions in good to excellent yields in the presence of tert-butoxide, water and air. The reaction is highly efficient, rapid, versatile, green and economical, and could find great practical application in organic synthesis, biochemistry, and industrial chemistry.

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Key Words

amidation, esters, radicals, potassium tert-butoxide, amides, green chemistry

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ID: J66-Y2012-0120