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A Thiophosphoryl Chloride Assisted Transformation of Arylaldoximes to Thioamides

Lokesh Kumar Pandey, Uma Pathak*, Sweta Mathur, M. V. S. Suryanarayana

*Synthetic Chemistry Division, Defence Research & Development Establishment, Gwalior (MP) 474 002, India, Email:

L. K. Pandey, U. Pathak, S. Mathur, M. V. S. Suryanarayana, Synthesis, 2012, 44, 272-282.

DOI: 10.1055/s-0031-1289994


A sequential tandem approach using thiophosphoryl chloride as a dehydrating and thionating agent enables the conversion of benzaldehyde oximes into primary benzothioamides via benzonitriles.

see article for more examples

Expeditious Microwave-Assisted Thionation with the System PSCl3/H2O/Et3N under Solvent-Free Condition

U. Pathak, L. K. Pandey, R. Tank, J. Org. Chem., 2008, 73, 2890-2893.

Key Words

primary thioamides, oximes, thiophosphoryl chloride, nitriles

ID: J66-Y2012-0200