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Copper-Catalyzed Oxidative Trifluoromethylation of Terminal Alkynes and Aryl Boronic Acids Using (Trifluoromethyl)trimethylsilane

Xueliang Jiang, Lingling Chu and Feng-Ling Qing*

*Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China, Email:

X. Jiang, L. Chu, F.-L. Qing, J. Org. Chem., 2012, 77, 1251-1257.

DOI: 10.1021/jo202566h (free Supporting Information)

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An efficient copper-catalyzed oxidative trifluoromethylation of terminal alkynes and aryl boronic acids in the presence of air is successfully achieved by adding both the substrate and a portion of CF3TMS slowly using a syringe pump to the reaction mixture.

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Copper-Mediated Aerobic Oxidative Trifluoromethylation of Terminal Alkynes with Me3SiCF3

L. Chu, F.-L. Qing, J. Am. Chem. Soc., 2010, 132, 7262-7263.

Key Words

trifluoromethyl alkynes, oxygen

ID: J42-Y2012-0210