Organic Chemistry Portal



Synthesis of Quinolines via Friedlšnder Reaction in Water and under Catalyst-Free Conditions

Qiang Shen, Limin Wang*, Jianjun Yu, Mingtao Liu, Jun Qiu, Lei Fang, Fenglou Guo, Jun Tang

*Shanghai Key Laboratory of Functional Materials Chemistry, and Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. of China, Email:

Q. Shen, L. Wang, J. Yu, M. Liu, J. Qiu, L. Fang, F. Guo, J. Tang, Synthesis, 2012, 44, 389-392.

DOI: 10.1055/s-0031-1289657

see article for more reactions


A straightforward and efficient method for the synthesis of quinolines via Friedlšnder reaction of 2-aminobenzaldehyde with various ketones or malononitrile can be conducted in water without using any catalyst at 70˚C.

see article for more examples

Key Words

catalyst-free, water, green chemistry, Friedlšnder reaction, ketones, quinolines

ID: J66-Y2012-0220