Synthesis of Quinolines via Friedländer Reaction in Water and under Catalyst-Free Conditions
Qiang Shen, Limin Wang*, Jianjun Yu, Mingtao Liu, Jun Qiu, Lei Fang, Fenglou Guo, Jun Tang
*Shanghai Key Laboratory of Functional Materials Chemistry,
and Institute of Fine Chemicals, East China University of Science and
Technology, 130 Meilong Road, Shanghai 200237, P. R. of China, Email: wanglimin
ecust.edu.cn
Q. Shen, L. Wang, J. Yu, M. Liu, J. Qiu, L. Fang, F. Guo, J. Tang, Synthesis, 2012, 44, 389-392.
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Abstract
A straightforward and efficient method for the synthesis of quinolines via Friedländer reaction of 2-aminobenzaldehyde with various ketones or malononitrile can be conducted in water without using any catalyst at 70˚C.
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Key Words
catalyst-free, water, green chemistry, Friedländer reaction, ketones, quinolines
ID: J66-Y2012-0220
