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Ruthenium-Catalyzed Oxidative C-H Bond Olefination of N-Methoxybenzamides Using an Oxidizing Directing Group

Bin Li*, Jianfeng Ma, Nuancheng Wang, Huiliang Feng, Shansheng Xu and Baiquan Wang*

*State Key Laboratory of Element-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China, Email: nklibinnankai.edu.cn, bqwangnankai.edu.cn

B. Li, J. Ma, N. Wang, H. Feng, S. Xu, B. Wang, Org. Lett., 2012, 14, 736-739.

DOI: 10.1021/ol2032575 (free Supporting Information)


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Abstract

Ruthenium-catalyzed oxidative C-H bond formation of N-methoxybenzamides using an oxidizing directing group gives ortho-substituted Heck-type products with acrylates in MeOH, whereas reactions with styrene (or norbornadiene) in CF3CH2OH affords 3,4-dihydroisoquinolinones.

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Key Words

Olefination


ID: J54-Y2012-0230