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Efficient Palladium-Catalyzed Cross-Coupling of Highly Acidic Substrates, Nitroacetates

Alison E. Metz, Simon Berritt, Spencer D. Dreher* and Marisa C. Kozlowski*

*Penn Merck High Throughput Experimentation Laboratory, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 1910-6323, United States, Email:;

A. E. Metz, S. Berritt, S. D. Dreher, M. C. Kozlowski, Org. Lett., 2012, 14, 760-763.

DOI: 10.1021/ol203303b (free Supporting Information)

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The use of tBuXPhos as ligand enabled palladium-catalyzed cross-coupling of aryl bromides with very acidic nitroacetates to afford 2-aryl-2-nitroacetates.

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Palladium-Catalyzed Nitromethylation of Aryl Halides: An Orthogonal Formylation Equivalent

R. R. Walvoord, S. Berritt, M. C. Kozlowski, Org. Lett., 2012, 14, 4086-4089.

Key Words

α-arylation, active methylene compounds

ID: J54-Y2012-0250