Efficient Palladium-Catalyzed Cross-Coupling of Highly Acidic Substrates, Nitroacetates
Alison E. Metz, Simon Berritt, Spencer D. Dreher* and Marisa C. Kozlowski*
*Penn Merck High Throughput Experimentation Laboratory,
Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania
1910-6323, United States, Email: spencer_dreher
merck.com;
marisasas.upenn.edu
A. E. Metz, S. Berritt, S. D. Dreher, M. C. Kozlowski, Org. Lett., 2012, 14, 760-763.
DOI: 10.1021/ol203303b
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Abstract
The use of tBuXPhos as ligand enabled palladium-catalyzed cross-coupling of aryl bromides with very acidic nitroacetates to afford 2-aryl-2-nitroacetates.
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Palladium-Catalyzed Nitromethylation of Aryl Halides: An Orthogonal Formylation Equivalent
R. R. Walvoord, S. Berritt, M. C. Kozlowski, Org. Lett., 2012, 14, 4086-4089.
Key Words
α-arylation, active methylene compounds
ID: J54-Y2012-0250
