Ligand-Free Ni-Catalyzed Reductive Cleavage of Inert Carbon-Sulfur Bonds

Nekane Barbero and Ruben Martin*

*Institute of Chemical Research of Catalonia (ICIQ), Av Països Catalans 16, 43007, Tarragona, Spain, Email: rmartinromoiciq.es

N. Barbero, R. Martin, Org. Lett., 2012, 14, 796-799.

DOI: 10.1021/ol2033306

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Abstract

A catalytic reductive cleavage of C(sp²)- and C(sp³)-SMe bonds under ligandless conditions offers a wide scope and high chemoselectivity profile including challenging substrate combinations, allowing the design of orthogonal and site-selectivity approaches.

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Key Words

desulfurization, silanes

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ID: J54-Y2012-0270