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Efficient Palladium-Catalyzed Cross-Coupling Reaction of Alkynyl Halides with Organoboronic Acids under Aerobic Conditions

Jian-Sheng Tang*, Mi Tian, Wen-Bing Sheng, Can-Cheng Guo*

*College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. of China, Email:,

J.-S. Tang, M. Tian, W.-B. Sheng, C.-C. Guo, Synthesis, 2012, 44, 541-546.

DOI: 10.1055/s-0031-1290159 (free Supporting Information)

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In the presence of bis(dibenzylideneacetone)palladium(0) and cesium carbonate, a variety of alkynyl halides underwent a ligand-free Suzuki-Miyaura cross-coupling reaction with organoboronic acids at room temperature under aerobic conditions to afford the corresponding unsymmetrical diarylalkynes in good yields.

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Key Words

palladium, alkynyl halides, organoboronic acids, cross-coupling reaction, alkynes, Suzuki Coupling

ID: J66-Y2012-0370