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Cu(I)-Catalyzed Synthesis of Imidazo[1,2-a]pyridines from Aminopyridines and Nitroolefins Using Air as the Oxidant

Ru-Long Yan*, Hao Yan, Chao Ma, Zhi-Yong Ren, Xi-Ai Gao, Guo-Sheng Huang* and Yong-Min Liang

*State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou 730000, P. R. of China, Email:,

R.-L. Yan, H. Yan, C. Ma, Z.-Y. Ren, X.-A. Gao, G.-S. Huang, Y.-M. Liang, J. Org. Chem., 2012, 77, 2024-2028.

DOI: 10.1021/jo202447p

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A copper-catalyzed one-pot procedure enables the synthesis of imidazo[1,2-a]pyridines with aminopyridines and nitroolefins using air as oxidant. This general reaction appears to be very suitable for the construction of various imidazo[1,2-a]pyridines.

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Iron(II)-Catalyzed Denitration Reaction: Synthesis of 3-Methyl-2-arylimidazo[1,2-a]pyridine Derivatives from Aminopyridines and 2-Methylnitroolefins

H. Yan, S. Yang, X. Gao, K. Zhou, C. Ma, R. Yan, G. Huang, Synlett, 2012, 23, 2961-2962.

Key Words

imidazo[1,2-a]pyridines, oxygen

ID: J42-Y2012-0430