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Palladium-Catalyzed Oxidative Heck Coupling Reaction for Direct Synthesis of 4-Arylcoumarins Using Coumarins and Arylboronic Acids

Yaming Li*, Zisong Qi, Huifeng Wang, Xinmei Fu and Chunying Duan*

*State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China, Email:,

Y. Li, Z. Qi, H. Wang, X. Fu, C. Duan, J. Org. Chem., 2012, 77, 2053-2057.

DOI: 10.1021/jo202577m


Palladium-catalyzed oxidative Heck coupling reaction of coumarins and arylboronic acids allows a direct synthesis of 4-arylcoumarins in good yields. The reaction also showed tolerance toward functional groups such as hydro, methoxy, diethylamino, nitro, and chloro groups.

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Key Words

coumarins, oxidative Heck reaction, oxygen

ID: J42-Y2012-0470