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Chiral Brønsted Acid Catalyzed Enantioselective Propargylation of Aldehydes with Allenylboronate

Leleti Rajender Reddy*

*Chemical and Analytical Development, Novartis Pharmaceutical Corporation, East Hanover, New Jersey 07936, United States, Email: Email: reddylrajenderyahoo.com

L. R. Reddy, Org. Lett., 2012, 14, 1142-1145.

DOI: 10.1021/ol300075n (free Supporting Information)


Abstract

A highly enantioselective chiral Brønsted acid catalyzed propargylation of aldehydes with allenylboronate allows a practical conversion of a broad range of substrate covering aryl, polyaryl, heteroaryl, α,β-unsaturated, and aliphatic aldehydes.


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Key Words

Propargylation


ID: J54-Y2012-0480