Synthesis of Benzisoxazolines by the Coupling of Arynes with Nitrones
Chun Lu, Anton V. Dubrovskiy and Richard C. Larock*
*Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States, Email: larockiastate.edu
C. Lu, A. V. Dubrovskiy, R. C. Larock, J. Org. Chem., 2012, 77, 2279-2284.
A broad range of substituted benzisoxazolines have been synthesized by a mild [3 + 2] cycloaddition of nitrones and arynes. The process tolerates various functional groups.
see article for more examples
Synthesis of Benzisoxazoles by the [3 + 2] Cycloaddition of in situ Generated Nitrile Oxides and Arynes
A. V. Dubrovskiy, R. C. Larock, Org. Lett., 2010, 12, 1180-1183.
benzo-fused O-Heterocycles, benzo-fused N-Heterocycles, Huisgen 1,3-dipolar Cycloaddition