Tetramethylfluoroformamidinium Hexafluorophosphate (TFFH) as a Mild Deoxofluorination Reagent
Gabriel Bellavance, Pascal Dubé*, Bao Nguyen
*Chemical Research & Development, Pfizer Worldwide Research &
Development, Eastern Point Road, Groton, CT 06340, USA, Email: pascal.dube
nalasengineering.com
G. Bellavance, P. Dubé, B. Nguyen, Synlett, 2012, 23, 569-572.
DOI: 10.1055/s-0031-1290336
Abstract
The solid, air-stable peptide coupling reagent TFFH (tetramethylfluoroformamidinium hexafluorophosphate) activates various alcohols towards deoxofluorination under mild conditions, that are even compatible with carbonyl functional groups.
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Key Words
deoxofluorination, fluoroformamidinium, fluoride, TFFH, fluorination, allylic fluorides, benzylic fluorides
ID: J60-Y2012-0560
