Ligand-Accelerated Pd-Catalyzed Ketone γ-Arylation via C-C Cleavage with Aryl Chlorides
Asraa Ziadi and Ruben Martin*
*Institute of Chemical Research of Catalonia (ICIQ), Av
Països Catalans 16, 43007, Tarragona, Spain, Email: rmartinromo
iciq.es
A. Ziadi, R. Martin, Org. Lett., 2012, 14, 1266-1269.
DOI: 10.1021/ol300119u
Abstract
A highly efficient Pd-catalyzed arylative ring expansion of cyclobutanols with aryl chlorides via C-C bond cleavage at low catalyst loadings tolerates a wide range of functional groups and substitution patterns, thus constituting a straightforward alternative for preparing rather elusive γ-arylated ketones.
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Key Words
ID: J54-Y2012-0590
