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Palladium-Catalyzed Direct Hydroxymethylation of Aryl Halides and Triflates with Potassium Acetoxymethyltrifluoroborate

Norio Murai, Masahiro Yonaga* and Keigo Tanaka*

*Discovery Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan, Email: k6-tanakahhc.eisai.co.jp, m-yonagahhc.eisai.co.jp

N. Murai, M. Yonaga, K. Tanaka, Org. Lett., 2012, 14, 1278-1281.

DOI: 10.1021/ol300149b (free Supporting Information)


Abstract

Suzuki-Miyaura cross-coupling of aryl halides and triflates with potassium acetoxymethyltrifluoroborate afforded the corresponding benzylic alcohols in good yields.

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Key Words

Benzylic Alcohols


ID: J54-Y2012-0620