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A Simple and Efficient Copper-Catalyzed Synthesis of N-Alkynylimidazoles

Man-Gang Wang, Jun Wu, Zhi-Cai Shang*

*Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. of China, Email:

M.-G. Wang, J. Wu, Z.-C. Shang, Synlett, 2012, 23, 589-594.

DOI: 10.1055/s-0031-1290340


A simple and efficient method enables the synthesis of N-alkynylheteroarenes from 1,1-dibromo-1-alkenes via a copper-catalyzed cross-coupling reaction. Good yields and functional-group tolerance were obtained with TMEDA as ligand using imidazole and benzimidazole substrates in dioxane.

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Key Words

N-alkynylimidazoles, 1,1-dibromo-1-alkenes, copper, cross-coupling reaction, alkynylation

ID: J60-Y2012-0630