Nickel-Catalyzed Intermolecular Insertion of Aryl Iodides to Nitriles: A Novel Method to Synthesize Arylketones

Jen-Chieh Hsieh*, Yen-Chung Chen, An-Yi Cheng and Hsiao-Chun Tseng

*Department of Chemistry, Tamkang University, New Taipei City, 25137, Taiwan, Email: jchsiehmail.tku.edu.tw

J.-C. Hsieh, Y.-C. Chen, A.-Y. Cheng, H.-C. Tseng, Org. Lett., 2012, 14, 1282-1285.

DOI: 10.1021/ol300153f

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Abstract

A NiCl₂(DME)/dppp/Zn system catalyzed an intermolecular insertion of aryl iodides to nitriles to provide variously substituted arylketone derivatives in good yields with tolerance of a wide variety of functional groups.

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Key Words

Aryl Ketones, Zinc

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ID: J54-Y2012-0640