Highly Chemoselective Reduction of Carbonyl Groups in the Presence of Aldehydes
Gulluzar Bastug, Steve Dierick, Frédéric Lebreux and István E. Markó*
*Laboratory of Organic and Medicinal Chemistry, Université
Catholique de Louvain, Bâtiment Lavoisier, Place Louis Pasteur 1 bte L4.01.02.
1348 Louvain-la-Neuve, Belgium, Email: istvan.marko
uclouvain.be
G. Bastug, S. Dierick, F. Lebreux, I. E. Markó, Org. Lett., 2012, 14, 1306-1309.
DOI: 10.1021/ol300188e
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Abstract
The use of diethylaluminum benzenethiolate enables an efficient discrimination between aldehydes and other carbonyl functions and allows a chemoselective in situ reduction of ketones and methyl esters in the presence of aldehydes without using traditional protecting group methodologies.
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Key Words
Reduction of Carbonyl Compounds, Reduction of Esters, DIBALH
ID: J54-Y2012-0690
