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Efficient and General Synthesis of 3-Aryl Coumarins Using Cyanuric Chloride

Koneni V. Sashidhara*, Gopala Reddy Palnati, Srinivasa Rao Avula, Abdhesh Kumar

*Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR-CDRI, Lucknow 226 001, India, Email:

K. V. Sashidhara, G. R. Palnati, S. R. Avula, A. Kumar, Synlett, 2012, 23, 611-621.

DOI: 10.1055/s-0031-1290344 (free Supporting Information)


The use of cyanuric chloride (2,4,6-trichloro-1,3,5-triazine) and N-methyl morpholine enables an efficient and general protocol for a rapid synthesis of substituted 3-aryl coumarins. A series of substituted phenyl acetic acids have been successfully reacted with substituted 2-hydroxy benzaldehydes to afford 3-aryl coumarins in good to excellent yields.

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Key Words

synthesis, 3-aryl coumarins, cyanuric chloride, 2-hydroxy benzaldehydes

ID: J60-Y2012-0720