Highly Regioselective AgNTf₂-Catalyzed Intermolecular Hydroamination of Alkynes with Anilines

Xu Zhang, Bin Yang, Guangzhao Li, Xin Shu, Divyesh C. Mungra, Jin Zhu*

*Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, Nanjing University, Nanjing 210093, P. R. of China, Email: jinznju.edu.cn

X. Zhang, B. Yang, G. Li, X. Shu, D. C. Mungra, J. Zhu, Synlett, 2012, 23, 622-626.

DOI: 10.1055/s-0031-1290341

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Abstract

The use of AgNTf₂ as catalyst enables a facile, economic, regioselective, and high-yielding protocol for the hydroamination of unsymmetrical internal alkynes under mild reaction conditions. This strategy is efficient to build complex structures from simple starting materials in an environmentally compatible fashion.

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Key Words

AgNTf₂ catalysis, intermolecular hydroamination, internal alkynes, β-enamino esters

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ID: J60-Y2012-0770