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Enantioselective Construction of Pyrrolidines by Palladium-Catalyzed Asymmetric [3 + 2] Cycloaddition of Trimethylenemethane with Imines

Barry M. Trost * and Steven M. Silverman

*Department of Chemistry, Stanford University, Stanford, California 94305-5080, United States, Email:

B. M. Trost, S. M. Silverman, J. Am. Chem. Soc., 2012, 134, 4941-4954.

DOI: 10.1021/ja210981a (free Supporting Information)

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An enantioselective, palladium-catalyzed [3 + 2] cycloaddition of trimethylenemethane (TMM) with imines in the presence of novel phosphoramidite ligands gives the corresponding pyrrolidine cycloadducts with excellent yields and selectivities.

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ID: J48-Y2012-0790