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Unexpected Synthesis of 2,4,5-Trisubstituted Oxazoles via a Tandem Aza-Wittig/Michael/Isomerization Reaction of Vinyliminophosphorane

Hai Xie, Ding Yuan and Ming-Wu Ding*

*Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan, 430079, People’s Republic of China, Email: ding5229yahoo.com.cn

H. Xie, D. Yuan, M.-W. Ding, J. Org. Chem., 2012, 77, 2954-2958.

DOI: 10.1021/jo202588j (free Supporting Information)


Abstract

A tandem reaction of a vinyliminophosphorane with various acyl chlorides gives unexpectedly 2,4,5-trisubstituted oxazoles in a one-pot fashion.

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Key Words

Oxazoles


ID: J42-Y2012-0830