Unexpected Synthesis of 2,4,5-Trisubstituted Oxazoles via a Tandem Aza-Wittig/Michael/Isomerization Reaction of Vinyliminophosphorane
Hai Xie, Ding Yuan and Ming-Wu Ding*
*Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan, 430079, People’s Republic of China, Email: ding5229yahoo.com.cn
H. Xie, D. Yuan, M.-W. Ding, J. Org. Chem., 2012, 77, 2954-2958.
DOI: 10.1021/jo202588j (free Supporting Information)
A tandem reaction of a vinyliminophosphorane with various acyl chlorides gives unexpectedly 2,4,5-trisubstituted oxazoles in a one-pot fashion.
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