Nickel-Catalyzed Cross-Coupling of Chromene Acetals and Boronic Acids
Thomas J. A. Graham and Abigail G. Doyle*
*Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States, Email: agdoyleprinceton.edu
T. J. A. Graham, A. G. Doyle, Org. Lett., 2012, 14, 1616-1619.
DOI: 10.1021/ol300364s (free Supporting Information)
Under base-free conditions, readily accessible 2-ethoxy-2H-chromenes undergo C-O activation and C-C bond formation in the presence of an inexpensive nickel catalyst and boronic acids. This modular and highly efficient protocol enables broad access to 2-substituted-2H-chromenes and has been applied to the late-stage incorporation of complex molecules.
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