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Indium-Catalyzed Henry-Type Reaction of Aldehydes with Bromonitroalkanes

Raquel G. Soengas*, Artur M. S. Silva*

*Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal, Email:,

R. G. Soengas, A. M. S. Silva, Synlett, 2012, 23, 873-876.

DOI: 10.1055/s-0031-1290617


An economical method to perform the addition of bromonitroalkanes to aldehydes affords the corresponding nitroalkanols in good yields using zinc in the presence of a catalytic amount of indium. This indium-catalyzed Henry reaction performs better than the classic base-catalyzed reaction in terms of yields and substrate scope, avoids the use of stoichiometric amounts of the expensive indium powder, and can be easily scaled up.

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Key Words

Henry reaction, bromonitroalkanes, indium, zinc, catalytic, nitroalkanols, sonochemistry

ID: J60-Y2012-0880