Indium-Catalyzed Henry-Type Reaction of Aldehydes with Bromonitroalkanes
Raquel G. Soengas*, Artur M. S. Silva*
*Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal, Email: artur.silvaua.pt, rsoengasua.pt
R. G. Soengas, A. M. S. Silva, Synlett, 2012, 23, 873-876.
An economical method to perform the addition of bromonitroalkanes to aldehydes affords the corresponding nitroalkanols in good yields using zinc in the presence of a catalytic amount of indium. This indium-catalyzed Henry reaction performs better than the classic base-catalyzed reaction in terms of yields and substrate scope, avoids the use of stoichiometric amounts of the expensive indium powder, and can be easily scaled up.
see article for more examples