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Copper-Catalyzed Alkylation of Benzoxazoles with Secondary Alkyl Halides

Peng Ren, Isuf Salihu, Rosario Scopelliti and Xile Hu *

*Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), SB-ISIC-LSCI, BCH 3305, Lausanne 1015, Switzerland, Email: xile.huepfl.ch

P. Ren, I. Salihu, R. Scopelliti, X. Hu, Org. Lett., 2012, 14, 1748-1751.

DOI: 10.1021/ol300348w (free Supporting Information)



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Abstract

A copper(I) complex catalyzes a direct alkylation of benzoxazoles using nonactivated secondary alkyl halides in the presence of bis[2-(N,N-dimethylamino)ethyl] ether.

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Key Words

benzoxazoles


ID: J54-Y2012-0950