Palladium-Catalyzed Direct C-H Bond Alkynylations of Heteroarenes Using gem-Dichloroalkenes
Lutz Ackermann*, Christoph Kornhaass and Yingjun Zhu
*Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077 Göttingen, Germany, Email: Lutz.Ackermannchemie.uni-goettingen.de
L. Ackermann, C. Kornhaass, Y. Zhu, Org. Lett., 2012, 14, 1824-1826.
DOI: 10.1021/ol300514d
Abstract
Palladium-catalyzed direct alkynylations of heteroarenes with inexpensive gem-dichloroalkenes as user-friendly electrophiles set the stage for a modular, step-economical synthesis of diversely decorated heteroaryl alkynes.
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Key Words
ID: J54-Y2012-1020