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Highly Enantioselective Synthesis of 2,3-Dihydroquinazolinones through Intramolecular Amidation of Imines

Muthuraj Prakash and Venkitasamy Kesavan*

*Department of Biotechnology, Bhupat and Jyothi Mehta School of Biosciences Building, Indian Institute of Technology Madras, Chennai 600036, India, Email:

M. Prakash, V. Kesavan, Org. Lett., 2012, 14, 1896-1899.

DOI: 10.1021/ol300518m

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The use of a readily available Sc(III)-inda-pybox complex as a catalyst enabled an enantioselective synthesis of 2,3-dihydroquinazolinones (DHQZs) via a metal catalyzed asymmetric intramolecular amidation of an imine.

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Key Words


ID: J54-Y2012-1090