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Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction in Water Using Cyclodextrin as a Phase Transfer Catalyst

Jung-Ah Shin, Yeong-Gweon Lim* and Kyung-Hee Lee

*4-2, Agency for Defense Development, Yuseong, P.O. Box 35-4, 305-600 Daejeon, Republic of Korea, Email:

J.-A. Shin, Y.-G. Lim, K.-H. Lee, J. Org. Chem., 2012, 77, 4117-4122.

DOI: 10.1021/jo3000095 (free Supporting Information)

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1,4-Disubstituted-1,2,3-triazoles were obtained in very good yields from azides and terminal alkynes in water in the presence of catalytic amount of β-cyclodextrin as a phase transfer catalyst. Also, one-pot reactions of alkyl bromides, sodium azide, and terminal alkynes were carried out successfully to give 1,4-disubstituted-1,2,3-triazoles.

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Key Words

Click Chemistry, Green Chemistry

ID: J42-Y2012-1220