A Transition-Metal-Free Cross-Coupling Reaction of Allylic Bromides with Aryl- and Vinylboronic Acids
Mitsuhiro Ueda*, Kota Nishimura, Ryo Kashima, Ilhyong Ryu*
*Department of Chemistry, Graduate School of Science, Osaka
Prefecture University, Sakai, Osaka 599-8531, Japan, Email: ryu
c.s.osakafu-u.ac.jp,
uedac.s.osakafu-u.ac.jp
M. Ueda, K. Nishimura, R. Kashima, I. Ryu, Synlett, 2012, 23, 1085-1089.
DOI: 10.1055/s-0031-1290656
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Abstract
A cross-coupling reaction between aryl- and vinylboronic acids and various allylic bromides proceeded without the use of a transition-metal catalyst to give the corresponding allylated products in good yields. The use of an inorganic base and a small amount of water is crucial in obtaining good performance in the present transition-metal-free reaction.
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Key Words
transition-metal-free, C-C bond formation, allylation of arenes, aryl- and vinylboronic acids
ID: J60-Y2012-1240
