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Consecutive Michael-Claisen Process for Cyclohexane-1,3-dione Derivative (CDD) Synthesis from Unsubstituted and Substituted Acetone

Dharminder Sharma, Bandna, Arun K. Shil, Bikram Singh, Pralay Das*

*Natural Plant Products Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176061, Himachel Pradesh, India, Email:

D. Sharma, Bandna, A. K. Shil, B. Singh, P. Das, Synlett, 2012, 23, 1199-1204.

DOI: 10.1055/s-0031-1290900

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Cyclohexane-1,3-dione derivatives synthesis from unreactive acetone has been accomplished through a consecutive Michael-Claisen process. Furthermore, the scope of different carbonyl compounds was investigated and resulted with similar consecutive Michael-Claisen process for CDD synthesis. The reaction exhibited remarkable regioselectivity in Michael addition followed by Claisen cyclization.

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Key Words

cyclohexane-1,3-diones, cyclohexanones, Michael Addition, Claisen Condensation, acetone, acrylate

ID: J60-Y2012-1390