Aerobic Oxidation of Propargylic Alcohols to α,β-Unsaturated Alkynals or Alkynones Catalyzed by Fe(NO3)3·9H2O, TEMPO and Sodium Chloride in Toluene
Jinxian Liu, Xi Xie, Shengming Ma*
*Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, 3663 North Zhongshan Lu, Shanghai 200062, P. R. of China, Email: masmsioc.ac.cn
J. Liu, X. Xie, S. Ma, Synthesis, 2012, 44, 1569-1576.
DOI: 10.1055/s-0031-1290811 (free Supporting Information)
A practical aerobic oxidation of propargylic alcohols using Fe(NO3)3•9H2O, TEMPO and sodium chloride in toluene at room temperature allows the conversion of propargylic alcohols to α,β-unsaturated alkynals or alkynones in good to excellent yields. This protocol can also be applied in industrial-scale production.
see article for more examples