Rhodium-Catalyzed Dynamic Kinetic Asymmetric Transformations of Racemic Tertiary Allylic Trichloroacetimidates with Anilines
Jeffrey S. Arnold and Hien M. Nguyen*
*Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United States, Email: hien-nguyenuiowa.edu
J. S. Arnold, H. M. Nguyen, J. Am. Chem. Soc., 2012, 134, 8380-8383.
DOI: 10.1021/ja302223p (free Supporting Information)
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A regio- and enantioselective amination of racemic tertiary allylic trichloroacetimidates with a variety of aniline nucleophiles in the presence of a chiral diene-ligated rhodium catalyst is a direct and efficient route to chiral α,α-disubstituted allylic N-arylamines in good yields with very good levels of regio- and enantioselectivity.
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J. S. Arnold, G. T. Cizio, H. M. Nguyen, Org. Lett., 2011, 13, 5576-5579.