Mild and Ligand-Free Pd(II)-Catalyzed Conjugate Additions to Hindered γ-Substituted Cyclohexenones
James A. Jordan-Hore, James N. Sanderson and Ai-Lan Lee*
*School of Engineering and Physical Sciences, Heriot-Watt
University, Edinburgh EH14 4AS, Scotland, United Kingdom, Email: a.lee
hw.ac.uk
J. A. Jordan-Hore, J. N. Sanderson, A.-L. Lee, Org. Lett., 2012, 14, 2508-2511.
DOI: 10.1021/ol300794a
Abstract
Ligand-free cationic Pd(II) catalyst is a highly active catalytic system for conjugate additions of boroxines to sterically hindered γ-substituted cyclohexenones in the presence of NaNO3 as an additive. More challenging γγ- and βγ-substrates also react well to produce products with quaternary centers in a highly diastereoselective fashion.
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Key Words
ID: J54-Y2012-1570
