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An Efficient Synthesis of Azetidines with (2-Bromoethyl)sulfonium Triflate

Sven P. Fritz, Juan F. Moya, Matthew G. Unthank, Eoghan M. McGarrigle*, Varinder K. Aggarwal*

*School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK Email:,

S. P. Fritz, J. F. Moya, M. G. Unthank, E. M. McGarrigle, V. K. Aggarwal, Synthesis, 2012, 44, 1584-1590.

DOI: 10.1055/s-0031-1290951 (free Supporting Information)


Easily accessible arylglycine derivatives were cyclized to azetidines by using commercially available (2-bromoethyl)sulfonium triflate in a simple and mild procedure, that offers a relatively broad scope.

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Key Words

annulations, cyclizations, heterocycles, azetidines, sulfur, ylides

ID: J66-Y2012-1610